Carbohydrate supplementation attenuates muscle glycogen loss during acute bouts of resistance exercise

Int J Sport Nutr Exerc Metab. 2000 Sep;10(3):326-39. doi: 10.1123/ijsnem.10.3.326.


The effects of carbohydrate (CHO) supplementation on muscle glycogen and resistance exercise performance were examined with eight highly resistance trained males (mean +/- SEM, age: 24.3 +/- 1.1 years, height: 171.9 +/- 2.0 cm, body mass: 85.7 +/- 3.5 kg; experience 9.9 +/- 2.0 years). Subjects participated in a randomized, double blind protocol with testing sessions separated by 7 days. Testing consisted of an initial isokinetic leg exercise before and after an isotonic resistance exercise (IRT) session consisting of 3 leg exercises lasting approximately 39 min. Subjects consumed a CHO (1.0 g body mass(-1)) or placebo treatment (PLC), prior to and every 10-min (0.5 g body mass(-1)) during the IRT. Muscle tissue was obtained from the m vastus lateralis after a supine rest (REST) immediately after the initial isokinetic test (POST-ISO) and immediately after the IRT (POST-IRT). The CHO treatment elicited significantly less muscle glycogen degradation from the POST-ISO to POST-IRT (126.9 +/- 6.5 to 109.7 +/- 7.1 wet weight(-1)) compared to PLC (121.4 +/- 8.1 to 88.3 +/- 6. 0 wet weight(-1)). There were no differences in isokinetic performance between the treatments. The results of this investigation indicate that the consumption of a CHO beverage can attenuate the decrease in muscle glycogen associated with isotonic resistance exercise but does not enhance the performance of isokinetic leg exercise.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Cross-Over Studies
  • Dietary Carbohydrates / pharmacology*
  • Double-Blind Method
  • Exercise / physiology*
  • Fatty Acids, Nonesterified / metabolism
  • Glycogen / metabolism*
  • Humans
  • Lactic Acid / metabolism
  • Male
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / metabolism


  • Blood Glucose
  • Dietary Carbohydrates
  • Fatty Acids, Nonesterified
  • Lactic Acid
  • Glycogen