Rho family GTPases: more than simple switches

Trends Cell Biol. 2000 Oct;10(10):415-9. doi: 10.1016/s0962-8924(00)01832-8.


Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.

Publication types

  • Review

MeSH terms

  • Guanosine Diphosphate / metabolism
  • Guanosine Triphosphate / metabolism
  • Signal Transduction / physiology*
  • rho GTP-Binding Proteins / metabolism*


  • Guanosine Diphosphate
  • Guanosine Triphosphate
  • rho GTP-Binding Proteins