Abstract
The influence of nitro substituents on the properties of adenosine and 1-deazaadenosine was studied. Combination of a nitro group at the 2-position with several N6 substituents such as cyclopentyl and m-iodobenzyl gave a series of analogues with good adenosine receptor affinity, showing directable selectivity for the A1, A2A and A3 adenosine receptor subtypes.
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / metabolism*
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Animals
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Binding Sites
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Humans
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Ligands
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Protein Binding
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Purinergic P1 Receptor Agonists
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Radioligand Assay
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Rats
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Receptor, Adenosine A2A
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Receptor, Adenosine A3
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Receptors, Purinergic P1 / metabolism
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Tubercidin / analogs & derivatives*
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Tubercidin / chemical synthesis
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Tubercidin / metabolism
Substances
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Ligands
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Purinergic P1 Receptor Agonists
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Receptor, Adenosine A2A
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Receptor, Adenosine A3
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Receptors, Purinergic P1
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Adenosine
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Tubercidin