Prognostic markers in patients with typical bronchial carcinoid tumors

J Clin Endocrinol Metab. 2000 Sep;85(9):3425-30. doi: 10.1210/jcem.85.9.6785.


Typical bronchial carcinoids are usually considered fairly benign tumors. Metastases do however occur, and up to 10% of the patients ultimately die from their disease. To identify prognostic markers, we immunostained 43 typical bronchial carcinoids with antibodies against 8 possibly relevant hormones, oncogenes, tumor suppressor genes, adhesion molecules, and proliferation markers. Altogether 12 patients (28%) had metastatic disease, of whom 10 had regional lymph node metastases at diagnosis. Distant metastases have occurred in 5 patients (12%); all of these have died from their disease. Patients with high expression of Ki-67 had shorter survival time (P < 0.01). None of the immunostained hormones correlated to distant metastases or shorter survival time, but gastrin-releasing peptide correlated to metastatic disease (P < 0.05). All patients who died had CD44-negative tumors (P < 0.001). Nuclear nm23 staining correlated to decreased risk for metastatic disease and distant metastases per se (P < 0.01). Bcl-2 and p53 were associated with increased risk for distant metastases (P < 0.05 and P < 0.01, respectively). We conclude that some patients with typical bronchial carcinoids die from their disease and that gastrin-releasing peptide, Bcl-2, and p53 may be of importance for the malignant transformation of the tumor. Moreover, CD44, nm23, and Ki-67 may give valuable prognostic information and help identify the patients at risk of disease-related death.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Apoptosis / physiology
  • Biomarkers, Tumor
  • Bronchial Neoplasms / diagnosis
  • Bronchial Neoplasms / metabolism*
  • Bronchial Neoplasms / pathology
  • Carcinoid Tumor / diagnosis
  • Carcinoid Tumor / metabolism*
  • Carcinoid Tumor / pathology
  • Female
  • Genes, Tumor Suppressor / genetics
  • Growth Substances / blood
  • Hormones / blood
  • Humans
  • Hyaluronan Receptors / blood
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Oncogenes / genetics
  • Prognosis
  • Survival Analysis


  • Biomarkers, Tumor
  • Growth Substances
  • Hormones
  • Hyaluronan Receptors