Thrombin signalling and protease-activated receptors

Nature. 2000 Sep 14;407(6801):258-64. doi: 10.1038/35025229.


How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Cells / metabolism
  • Blood Vessels / metabolism
  • Endopeptidases / metabolism*
  • Endothelium, Vascular / metabolism
  • Humans
  • Platelet Activation
  • Receptors, Thrombin / metabolism*
  • Signal Transduction*
  • Thrombin / metabolism*


  • Receptors, Thrombin
  • Endopeptidases
  • Thrombin