The regulation of arginine biosynthesis in Saccharomyces cerevisiae. The specificity of argR- mutations and the general control of amino-acid biosynthesis

Eur J Biochem. 1975 Sep 1;57(1):231-9. doi: 10.1111/j.1432-1033.1975.tb02295.x.


The regulation of arginine biosynthetic enzymes in yeast is subjected to a double control. One level of arginine enzyme synthesis is under the control of an apo-repressor, called ARGR. ARGR molecules control specifically the arginine pathway. A second level of control of arginine biosynthesis has been disclosed. It also controls tryptophan, histidine, lysine, isoleucine-valine and probably many more biosyntheses. The general mechanism is turned on in leaky mutants in any of the amino acid pathways mentioned above.

MeSH terms

  • Amino Acids / biosynthesis*
  • Ammonia / metabolism
  • Arginine / biosynthesis*
  • Argininosuccinate Lyase / metabolism
  • Genotype
  • Mutation*
  • Ornithine Carbamoyltransferase / metabolism
  • Saccharomyces cerevisiae / metabolism*
  • Species Specificity


  • Amino Acids
  • Ammonia
  • Arginine
  • Ornithine Carbamoyltransferase
  • Argininosuccinate Lyase