The use of recombinant human TSH in a patient with metastatic follicular carcinoma and insufficient endogenous TSH production

J Endocrinol Invest. 2000 Jul-Aug;23(7):473-5. doi: 10.1007/BF03343758.

Abstract

We present a case of a patient suffering from metastatic differentiated thyroid carcinoma (DTC) and insufficient endogenous TSH production suspicious of secondary hypothyroidism. The use of recombinant human TSH (rhTSH) enabled us to administer a therapeutic activity of radioactive iodine (RAI) under maximal TSH-stimulation, achieving a marked decrease in thyroglobulin accompanied by a clinical improvement.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Follicular / complications*
  • Adenocarcinoma, Follicular / radiotherapy
  • Adenocarcinoma, Follicular / surgery
  • Bone Neoplasms / secondary
  • Humans
  • Hypothyroidism / drug therapy
  • Hypothyroidism / etiology
  • Iodine Radioisotopes / therapeutic use
  • Male
  • Middle Aged
  • Neoplasm Metastasis*
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / therapeutic use
  • Skull Neoplasms / secondary
  • Skull Neoplasms / surgery
  • Thyroid Neoplasms / complications*
  • Thyroid Neoplasms / radiotherapy
  • Thyroid Neoplasms / surgery
  • Thyroidectomy
  • Thyrotropin / administration & dosage
  • Thyrotropin / deficiency*
  • Thyrotropin / therapeutic use*

Substances

  • Iodine Radioisotopes
  • Recombinant Proteins
  • Thyrotropin