Live or Let Die - Retinal Ganglion Cell Death and Survival During Development and in the Lesioned Adult CNS

Trends Neurosci. 2000 Oct;23(10):483-90. doi: 10.1016/s0166-2236(00)01637-4.

Abstract

Programmed cell death or apoptosis is a common and widespread phenomenon that is important for proper development of the nervous system. In the adult CNS, however, apoptosis contributes to secondary cell loss after various types of lesions. The retino-tectal system has been successfully used as a convenient model system to study the molecular mechanisms of neuronal apoptosis and survival during development and in the lesioned adult CNS. This review describes the current knowledge about the interactions of cell death and survival pathways in general and for retinal ganglion cells specifically.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Animals
  • Apoptosis / physiology*
  • Apoptotic Protease-Activating Factor 1
  • Brain Injuries / pathology*
  • Brain-Derived Neurotrophic Factor / pharmacology
  • Brain-Derived Neurotrophic Factor / physiology
  • Caenorhabditis elegans / cytology
  • Caenorhabditis elegans / embryology
  • Caenorhabditis elegans / growth & development
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology
  • Caspases / deficiency
  • Caspases / genetics
  • Caspases / physiology*
  • Cell Survival
  • Chick Embryo
  • Genes, bcl-2
  • Helminth Proteins / physiology
  • Humans
  • Mice
  • Mice, Knockout
  • Mitochondria / physiology
  • Morphogenesis
  • Nerve Tissue Proteins / deficiency
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology
  • Proteins / genetics
  • Proteins / physiology
  • Proto-Oncogene Proteins / deficiency
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-bcl-2 / deficiency
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / physiology*
  • Retina / cytology
  • Retina / embryology
  • Retina / growth & development*
  • Retinal Ganglion Cells / cytology*
  • Retinal Ganglion Cells / metabolism
  • Retinal Ganglion Cells / pathology
  • bcl-2-Associated X Protein
  • bcl-Associated Death Protein
  • bcl-X Protein

Substances

  • APAF1 protein, human
  • Apaf1 protein, mouse
  • Apoptotic Protease-Activating Factor 1
  • BAD protein, human
  • BCL2L1 protein, human
  • Bad protein, mouse
  • Bcl2l1 protein, mouse
  • Brain-Derived Neurotrophic Factor
  • Carrier Proteins
  • Helminth Proteins
  • Nerve Tissue Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • bcl-2-Associated X Protein
  • bcl-Associated Death Protein
  • bcl-X Protein
  • Caspases