Cyclooxygenase mechanisms

Curr Opin Chem Biol. 2000 Oct;4(5):545-52. doi: 10.1016/s1367-5931(00)00130-7.


Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in substrate binding and oxygenation has been elucidated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arachidonic Acid / metabolism
  • Binding Sites
  • Heme / metabolism
  • Oxidants / metabolism
  • Prostaglandin-Endoperoxide Synthases / metabolism*
  • Substrate Specificity


  • Oxidants
  • Arachidonic Acid
  • Heme
  • Prostaglandin-Endoperoxide Synthases