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. 2000 Oct;4(5):567-72.
doi: 10.1016/s1367-5931(00)00133-2.

Modular Evolution of the Purine Biosynthetic Pathway


Modular Evolution of the Purine Biosynthetic Pathway

T J Kappock et al. Curr Opin Chem Biol. .


Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.

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