Modular evolution of the purine biosynthetic pathway

Curr Opin Chem Biol. 2000 Oct;4(5):567-72. doi: 10.1016/s1367-5931(00)00133-2.


Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Evolution, Molecular*
  • Models, Molecular
  • Proteins / chemistry
  • Purines / biosynthesis*
  • Purines / chemistry


  • Proteins
  • Purines