Cytokine-secreting tumor cell vaccines

Curr Opin Immunol. 2000 Oct;12(5):571-5. doi: 10.1016/s0952-7915(00)00144-8.


Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cancer Vaccines / immunology*
  • Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
  • Humans
  • Interleukin-12 / metabolism*


  • Cancer Vaccines
  • Interleukin-12
  • Granulocyte-Macrophage Colony-Stimulating Factor