Effects of Beta-Hydroxy-Beta-Methylbutyrate on Muscle Damage After a Prolonged Run

J Appl Physiol (1985). 2000 Oct;89(4):1340-4. doi: 10.1152/jappl.2000.89.4.1340.

Abstract

This study examined the effects of supplemental beta-hydroxy-beta-methylbutyrate (HMB) on muscle damage as a result of intense endurance exercise. Subjects (n = 13) were paired according to their 2-mile run times and past running experience. Each pair was randomly assigned a treatment of either HMB (3 g/day) or a placebo. After 6 wk of daily training and supplementation, all subjects participated in a prolonged run (20-km course). Creatine phosphokinase and lactate dehydrogenase (LDH) activities were measured before and after a prolonged run to assess muscle damage. The placebo-supplemented group exhibited a significantly greater (treatment main effect, P = 0.05) increase in creatine phosphokinase activity after a prolonged run than did the HMB-supplemented group. In addition, LDH activity was significantly lower (treatment main effect, P = 0.003) with HMB supplementation compared with the placebo-supplemented group. In conclusion, supplementation with 3.0 g of HMB results in a decreased creatine phosphokinase and LDH response after a prolonged run. These findings support the hypothesis that HMB supplementation helps prevent exercise-induced muscle damage.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Body Composition
  • Creatine Kinase / blood
  • Dietary Supplements
  • Female
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Male
  • Middle Aged
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / physiology
  • Muscle, Skeletal / physiopathology
  • Oxygen Consumption / drug effects*
  • Placebos
  • Running / physiology*
  • Valerates / administration & dosage
  • Valerates / blood
  • Valerates / pharmacology*

Substances

  • Placebos
  • Valerates
  • beta-hydroxyisovaleric acid
  • L-Lactate Dehydrogenase
  • Creatine Kinase