Endocapillary proliferative glomerulonephritis in a patient with parvovirus B19 infection

Am J Kidney Dis. 2000 Oct;36(4):851-4. doi: 10.1053/ajkd.2000.17718.

Abstract

A 45-year-old woman developed acute nephritic syndrome after erythema infectiosum. Laboratory data on admission showed decreased serum C3, C4, and CH50 levels and the presence of both immunoglobulin (Ig) M and IgG antibodies to human parvovirus B19 (HPV). A renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. Immunofluorescence microscopy indicated 2+ granular staining for IgG, IgM, and C3 over the mesangial area and along glomerular capillary walls. HPV antigen was also detected in glomeruli by immunohistochemistry. Electron microscopy showed electron-dense deposits in the subendothelial space and the paramesangial area. These findings suggest that immune complex-type glomerulonephritis is caused by glomerular deposition of HPV antigen-antibody complexes in some patients with HPV infection.

Publication types

  • Case Reports

MeSH terms

  • Antigen-Antibody Complex
  • Antigens, Viral / analysis
  • Complement System Proteins / analysis
  • Erythema Infectiosum / complications*
  • Erythema Infectiosum / immunology
  • Female
  • Glomerulonephritis / complications*
  • Glomerulonephritis / immunology
  • Glomerulonephritis / virology
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Middle Aged
  • Nephrotic Syndrome / etiology*
  • Nephrotic Syndrome / immunology
  • Parvovirus B19, Human* / immunology

Substances

  • Antigen-Antibody Complex
  • Antigens, Viral
  • Immunoglobulin G
  • Immunoglobulin M
  • Complement System Proteins