Molecular identification of a glucose transporter from fish muscle

FEBS Lett. 2000 Sep 22;481(3):266-70. doi: 10.1016/s0014-5793(00)02020-2.


In mammals and birds, several isoforms of facilitative glucose transporters have been identified (GLUT1-4), but no information is available regarding the molecules involved in glucose transport in other vertebrates. Here we report the cloning of a GLUT molecule from fish muscle with high sequence homology to GLUT4 and containing features characteristic of a functional GLUT. Fish GLUT is expressed predominantly in skeletal muscle, kidney and gill, which are tissues with known high glucose utilization. These results indicate that fish GLUT is structurally, and perhaps functionally, similar to the other known GLUTs expressed in muscle in mammalian and avian species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport, Active
  • Blotting, Northern
  • Cloning, Molecular
  • Glucose / metabolism*
  • Glucose Transporter Type 4
  • Humans
  • Molecular Sequence Data
  • Monosaccharide Transport Proteins / biosynthesis
  • Monosaccharide Transport Proteins / chemistry
  • Monosaccharide Transport Proteins / genetics
  • Monosaccharide Transport Proteins / isolation & purification*
  • Muscle Proteins*
  • Muscle, Skeletal / chemistry*
  • Muscle, Skeletal / metabolism
  • Organ Specificity / genetics
  • Sequence Alignment
  • Sequence Analysis, Protein
  • Sequence Homology, Amino Acid
  • Trout


  • Glucose Transporter Type 4
  • Monosaccharide Transport Proteins
  • Muscle Proteins
  • SLC2A4 protein, human
  • Glucose

Associated data

  • GENBANK/AF247395