The thin red line: angiogenesis in normal and malignant hematopoiesis

Exp Hematol. 2000 Sep;28(9):993-1000. doi: 10.1016/s0301-472x(00)00508-7.


This review describes the current knowledge about cell subsets involved in vasculogenesis (i.e., differentiation of endothelial cells from mesodermal precursors) and angiogenesis (i.e., blood vessel generation from pre-existing vessels), together with recent findings about angiogenesis and antiangiogenic therapies in hematopoietic malignancies such as leukemia, lymphoma, myeloma, and myelodysplastic syndromes.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Hematologic Neoplasms / physiopathology*
  • Hematopoiesis / physiology
  • Humans
  • Neovascularization, Pathologic / physiopathology*
  • Neovascularization, Physiologic / physiology
  • Stem Cells / immunology
  • Stem Cells / physiology


  • Antineoplastic Agents