The diagnosis and management of dry eye: a twenty-five-year review

Cornea. 2000 Sep;19(5):644-9. doi: 10.1097/00003226-200009000-00009.


Purpose: To review the advances in the diagnosis, pathogenesis, and management of dry eye disease in the past 25 years.

Methods: Literature review.

Results: The preocular tear film is a hydrated mucus gel that contains soluble antimicrobial proteins and growth factors that protect and support the ocular surface. The final common pathway in dry eye is a perturbation of the integrated ocular surface/lacrimal gland reflex unit. Diagnostic tests evaluating tear composition and clearance appear to show stronger correlation with the severity of ocular irritation symptoms and keratoconjunctivitis sicca (KCS) than the conventional Schirmer tests. KCS is a condition of abnormal differentiation and mucus production by the ocular surface epithelium that results in a poorly lubricated, abnormally permeable ocular surface that has increased susceptibility to environmental insults. Chronic subclinical ocular surface inflammation appears to play a key role in the pathogenesis of KCS. New therapeutic strategies are aimed at reducing the ocular surface inflammation of dry eye disease.

Conclusions: There has been a tremendous increase in knowledge regarding dry eye disease in the past 25 years that has resulted in improved diagnostic classification and new targeted therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Diagnostic Techniques, Ophthalmological / trends
  • Dry Eye Syndromes / diagnosis*
  • Dry Eye Syndromes / metabolism
  • Dry Eye Syndromes / therapy*
  • Humans
  • Lacrimal Apparatus / metabolism
  • Ophthalmic Solutions / therapeutic use
  • Prognosis
  • Tears / metabolism


  • Anti-Inflammatory Agents
  • Ophthalmic Solutions