Probing biopolymers with the atomic force microscope: a review

J Biomater Sci Polym Ed. 2000;11(7):675-83. doi: 10.1163/156856200743940.


This short review presents an overview of atomic force microscopy (AFM) of biopolymers and specific examples of some of the biopolymers that have been analyzed by AFM. These specific examples include extracellular polymeric substances on the surfaces of bacterial biofilms, condensed DNA, DNA constructs, and DNA-protein interactions. In addition, two examples are presented for AFM analyses of proteins: laminin flexing its arms in solution and neurofilaments entropically brushing away the space around themselves.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacteria / ultrastructure
  • Biofilms
  • Biopolymers / chemistry*
  • DNA / chemistry*
  • Microscopy, Atomic Force / methods*
  • Proteins / chemistry*


  • Biopolymers
  • Proteins
  • DNA