Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
, 14 (10), 1353-8

(13)C-urea Breath Test Without a Test Meal Is Highly Accurate for the Detection of Helicobacter Pylori Infection in Chinese

Affiliations
Clinical Trial

(13)C-urea Breath Test Without a Test Meal Is Highly Accurate for the Detection of Helicobacter Pylori Infection in Chinese

W M Wong et al. Aliment Pharmacol Ther.

Abstract

Background: Conventional (13)C-urea breath testing ((13)C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary.

Aim: To investigate a new (13)C-UBT protocol without a test meal in a Chinese population.

Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. (13)C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology).

Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of (13)C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to (13)C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%).

Conclusion: This simplified (13)C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.

Similar articles

See all similar articles

Cited by 7 PubMed Central articles

See all "Cited by" articles

Publication types

Feedback