Calciphylaxis in the absence of renal failure

Clin Exp Dermatol. 2000 Jul;25(5):389-92. doi: 10.1046/j.1365-2230.2000.00671.x.


We report a patient with severe bilateral leg ulceration that was resistant to treatment. A biopsy confirmed the cause as calciphylaxis. Calciphylaxis refers to a syndrome of calcium deposition in the small and intermediate dermal vasculature which can lead to epidermal ischaemia, ulceration and necrosis. Most cases occur in those with chronic renal failure and secondary hyperparathyroidism. We describe the rare presentation of calciphylaxis in a patient with normal renal function and primary hyperparathyroidism who had many classical features. Unfortunately she developed gangrene, sepsis and died.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amputation
  • Biopsy
  • Calciphylaxis / complications*
  • Calciphylaxis / pathology
  • Calciphylaxis / surgery
  • Fatal Outcome
  • Female
  • Humans
  • Leg Ulcer / etiology*
  • Leg Ulcer / pathology
  • Leg Ulcer / surgery
  • Prognosis