Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients

Clin Lab Haematol. 2000 Aug;22(4):215-20. doi: 10.1046/j.1365-2257.2000.00307.x.

Abstract

Angiocentric T cell/natural killer (NK) nasal lymphoma remains a rare clinical presentation in North America and Europe but is more common in Asia and Latin America. We have reviewed 108 cases of angiocentric T/NK cell lymphoma of the nasal cavity with a view to establishing prognostic factors. Most patients were high or high intermediate clinical risk and had additional poor prognostic factors such as bulky disease, high levels of beta 2 microglobulin, advanced stage and multiple extranodal involvement. At 8 years, overall survival was 82%, 90% and 84% for low-intermediate, high-intermediate and high clinical, respectively. Disease free survival was very similar: 79%, 83% and 80%, respectively. Multivariate analysis did not identify any factor influencing overall survival and disease-free survival. There was no evidence that the international prognostic index (IPI) was applicable in these patients and it appears that angiocentric T/NK cell lymphoma is an independent prognostic factor itself.

MeSH terms

  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Killer Cells, Natural*
  • L-Lactate Dehydrogenase / blood
  • Lymphoma, T-Cell / diagnosis*
  • Lymphoma, T-Cell / epidemiology
  • Male
  • Mexico / epidemiology
  • Middle Aged
  • Nose Neoplasms / diagnosis*
  • Nose Neoplasms / epidemiology
  • Prognosis
  • Risk Factors
  • Survival Rate
  • beta 2-Microglobulin / blood

Substances

  • beta 2-Microglobulin
  • L-Lactate Dehydrogenase