Quantitative trait loci affecting prion incubation time in mice

Genomics. 2000 Oct 1;69(1):47-53. doi: 10.1006/geno.2000.6320.


Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Crosses, Genetic
  • Female
  • Genetic Linkage
  • Genome
  • Lod Score
  • Male
  • Mice
  • Mice, Inbred Strains
  • Microsatellite Repeats
  • PrPSc Proteins / genetics*
  • Prion Diseases / genetics*
  • Quantitative Trait, Heritable*
  • Scrapie / genetics
  • Species Specificity
  • Time Factors


  • PrPSc Proteins