Successful treatment of bilateral renal fungal balls with liposomal amphotericin B and fluconazole in an extremely low birth weight infant

Eur J Pediatr. 2000 Sep;159(9):676-8. doi: 10.1007/pl00008405.

Abstract

At the age of 8 weeks, an extremely low birth weight infant (gestational age 26 0/7 weeks, birth weight 740 g) had non-obstructing bilateral renal fungal balls. Urine cultures had repeatedly grown Candida albicans. Combination therapy with liposomal amphotericin B intravenously and fluconazole orally was administered for 6 weeks. Monotherapy with fluconazole was then continued until complete resolution of the renal fungal balls.

Conclusion: Combination therapy with liposomal amphotericin B and fluconazole was successful in eliminating non-obstructing bilateral renal fungal balls and obviated the need for surgical intervention.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Candidiasis / drug therapy*
  • Drug Therapy, Combination
  • Fluconazole / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infant, Very Low Birth Weight
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / microbiology
  • Remission Induction

Substances

  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Fluconazole