nm23 Expression in choroidal melanoma

Ophthalmic Res. Nov-Dec 2000;32(6):257-60. doi: 10.1159/000055623.

Abstract

nm23 protein expression of choroidal melanoma was investigated to determine its relationship with clinical and histopathological characteristics of the tumour. Thirty-four consecutive choroidal melanoma patients were examined by immunohistochemistry. Although age, sex, tumour cell type, tumour size, pigmentation, necrosis, apoptosis and tumour lymphocytic infiltration were not correlated with nm23 protein expression, tumours with low percentages of nm23-positive cells revealed higher nuclear grades and predominant mitotic figures. nm23 may be associated with melanoma progression, but there is no proof that it plays a role in the metabolic process of the tumour.

MeSH terms

  • Adult
  • Aged
  • Antigens, Neoplasm / metabolism*
  • Biomarkers, Tumor / metabolism*
  • Choroid Neoplasms / metabolism*
  • Choroid Neoplasms / pathology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Middle Aged
  • Monomeric GTP-Binding Proteins / metabolism*
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleoside-Diphosphate Kinase*
  • Transcription Factors / metabolism*

Substances

  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • NM23 Nucleoside Diphosphate Kinases
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins