Abstract
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Amino Acid Sequence
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Calpain / chemistry
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Calpain / genetics*
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Chromosome Mapping
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Chromosomes, Human, Pair 2*
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Diabetes Mellitus, Type 2 / enzymology
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Diabetes Mellitus, Type 2 / epidemiology
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Diabetes Mellitus, Type 2 / genetics*
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European Continental Ancestry Group / genetics
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Finland
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Gene Frequency
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Genetic Markers
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Genetic Predisposition to Disease*
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Genetic Variation*
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Genome, Human
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Haplotypes
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Humans
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Mexican Americans / genetics
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Molecular Sequence Data
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Polymorphism, Genetic*
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Risk Assessment
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United States
Substances
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Genetic Markers
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Calpain
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calpain 10
Associated data
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GENBANK/AF089087
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GENBANK/AF089088
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GENBANK/AF089089
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GENBANK/AF089090
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GENBANK/AF089091
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GENBANK/AF089092
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GENBANK/AF089093
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GENBANK/AF089094
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GENBANK/AF089095
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GENBANK/AF089096
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GENBANK/AF158748
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GENBANK/AF200349
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GENBANK/AF300795