Biofilm Formation as Microbial Development

Annu Rev Microbiol. 2000;54:49-79. doi: 10.1146/annurev.micro.54.1.49.

Abstract

Biofilms can be defined as communities of microorganisms attached to a surface. It is clear that microorganisms undergo profound changes during their transition from planktonic (free-swimming) organisms to cells that are part of a complex, surface-attached community. These changes are reflected in the new phenotypic characteristics developed by biofilm bacteria and occur in response to a variety of environmental signals. Recent genetic and molecular approaches used to study bacterial and fungal biofilms have identified genes and regulatory circuits important for initial cell-surface interactions, biofilm maturation, and the return of biofilm microorganisms to a planktonic mode of growth. Studies to date suggest that the planktonic-biofilm transition is a complex and highly regulated process. The results reviewed in this article indicate that the formation of biofilms serves as a new model system for the study of microbial development.

Publication types

  • Review

MeSH terms

  • Biofilms / growth & development*
  • Cell Adhesion
  • Fungi / physiology*
  • Gram-Negative Bacteria / physiology*
  • Gram-Positive Bacteria / physiology*
  • Models, Biological