Spectral analysis of electroencephalogram during sleep-related apneas in pre-term and term born infants in the first weeks of life

Clin Neurophysiol. 2000 Oct;111(10):1788-91. doi: 10.1016/s1388-2457(00)00417-x.


Objectives: A correlation between sudden infant death syndrome (SIDS) and apnea has been discussed in a variety of studies. We analyzed polysomnographic data in 51 infants and investigated correlations between the manifestation of apneas and changes in EEG pattern.

Methods: Measurements were performed by means of the commercial polysomnographic device 'ALICE III'. Spectral analysis of certain parts of the registered EEG was performed.

Results: During apnea a reduction of the EEG amplitude was seen. The extent of the decrease differed slightly between the frequency bands.

Conclusions: According to the widespread agreement that a lower voltage of electrical brain activity is a fundamental sign of waking up, we hypothesize that the observed change might be an immature type of arousal reaction.

MeSH terms

  • Brain / physiopathology*
  • Electroencephalography
  • Humans
  • Infant
  • Infant, Newborn
  • Sleep / physiology
  • Sleep Apnea Syndromes / physiopathology*