Identification of two novel human CD1E alleles

Tissue Antigens. 2000 Aug;56(2):159-61. doi: 10.1034/j.1399-0039.2000.560208.x.

Abstract

CD1 is a family of proteins structurally related to major histocompatibility complex (MHC) molecules and specialized in presenting lipids or glycolipids to T cells. In humans, there are five CD1 genes (CD1A to CD1E). It has been shown that, in contrast with classical MHC genes, CD1 loci display a very limited polymorphism. In the present work we describe two novel CD1E alleles found in two healthy Caucasian individuals. One allele differs from the wild-type by a point mutation resulting in a replacement of arginine at position 154 by a tryptophan. In the second allele we found a substitution of the leucine 184 by a proline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Amino Acid Sequence
  • Antigens, CD1 / chemistry*
  • Antigens, CD1 / genetics*
  • Antigens, CD1 / immunology
  • Base Sequence
  • Exons
  • Humans
  • Molecular Sequence Data
  • Point Mutation / immunology
  • Polymorphism, Single Nucleotide / immunology
  • Polymorphism, Single-Stranded Conformational
  • Protein Structure, Tertiary

Substances

  • Antigens, CD1
  • CD1e antigen