After-cataract and secondary glaucoma in the aphakic infant rabbit

J Cataract Refract Surg. 2000 Sep;26(9):1398-402. doi: 10.1016/s0886-3350(00)00408-9.


Purpose: To study the association between after-cataract and secondary glaucoma after lensectomy and 5-fluorouracil treatment in an experimental infant rabbit model.

Setting: St Erik Eye Hospital, Karolinska Institute, Stockholm, Sweden.

Methods: Lensectomy was performed in both eyes of 16 3-week-old rabbits. One randomly selected eye in each rabbit was injected with 2.5 mg of 5-fluorouracil (5-FU) at surgery and 5.0 mg the day after surgery to reduce the formation of after-cataract. Axial length, corneal thickness, corneal diameter, and intraocular pressure were measured preoperatively and 4 times during the 6 months following surgery. Six months after surgery, the wet weight of the after-cataract was determined.

Results: In 16 aphakic eyes treated with 5-FU, no or a minimal amount (<0.001 g) of after-cataract developed. None of the eyes showed signs of secondary glaucoma. Of 16 aphakic eyes not treated with 5-FU, 10 developed considerable amounts of after-cataract (>0.10 g); 8 of these developed glaucoma. The other 6 eyes had no or minimal after-cataract and did not develop secondary glaucoma. The relationship between after-cataract and secondary glaucoma was statistically significant.

Conclusion: A significant relationship between the amount of after-cataract and the development of secondary glaucoma was found in aphakic infant rabbit eyes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Anterior Chamber
  • Aphakia, Postcataract / complications*
  • Cataract / etiology*
  • Cataract / pathology
  • Fluorouracil / administration & dosage
  • Glaucoma / etiology*
  • Glaucoma / physiopathology
  • Glaucoma / prevention & control
  • Immunosuppressive Agents / administration & dosage
  • Injections
  • Intraocular Pressure / physiology*
  • Lens Capsule, Crystalline / pathology*
  • Phacoemulsification / adverse effects*
  • Postoperative Complications / pathology*
  • Rabbits


  • Immunosuppressive Agents
  • Fluorouracil