Differences that matter: major cytotoxic T cell-stimulating minor histocompatibility antigens

Immunity. 2000 Sep;13(3):333-44. doi: 10.1016/s1074-7613(00)00033-9.

Abstract

Despite thousands of genetic polymorphisms among MHC matched mouse strains, a few unknown histocompatibility antigens are targeted by the cytotoxic T cells specific for tissue grafts. We isolated the cDNA of a novel BALB.B antigen gene that defines the polymorphic H28 locus on chromosome 3 and yields the naturally processed ILENFPRL (IFL8) peptide for presentation by Kb MHC to C57BI/6 CTL. The CTL specific for the IFL8/Kb and our previously identified H60/Kb complexes represent a major fraction of the B6 anti-BALB.B immune response. The immunodominance of these antigens can be explained by their differential transcription in the donor versus the host strains and their expression in professional donor antigen-presenting cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation / genetics
  • Antigen-Presenting Cells / immunology
  • Antigen-Presenting Cells / metabolism
  • Base Sequence
  • Cell Line
  • Cytotoxicity, Immunologic* / genetics
  • Epitopes, T-Lymphocyte / immunology
  • H-2 Antigens / immunology
  • H-2 Antigens / metabolism
  • Lymphocyte Activation* / genetics
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Minor Histocompatibility Antigens / genetics
  • Minor Histocompatibility Antigens / immunology*
  • Minor Histocompatibility Antigens / isolation & purification
  • Minor Histocompatibility Antigens / metabolism
  • Minor Histocompatibility Loci
  • Molecular Sequence Data
  • Oligopeptides / genetics
  • Oligopeptides / immunology
  • Oligopeptides / metabolism
  • Protein Binding / genetics
  • Protein Binding / immunology
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / metabolism
  • Transcription, Genetic / immunology

Substances

  • Epitopes, T-Lymphocyte
  • H-2 Antigens
  • H-2Kb protein, mouse
  • H28 antigen
  • Minor Histocompatibility Antigens
  • Oligopeptides
  • minor H antigen H60