Endoscopic therapy for stenosis of the biliary and pancreatic duct orifices

Gastrointest Endosc. 2000 Oct;52(4):500-5. doi: 10.1067/mge.2000.108715.


Background: Manipulation of the duodenal papilla may lead to symptomatic stenosis of the orifices of bile duct, main pancreatic duct or accessory pancreatic duct.

Methods: Seventeen patients with stenosis of the orifice (bile duct 7, bile duct/main pancreatic duct 7, accessory pancreatic duct 3) underwent sphincterotomy and/or dilation and stent placement for a median of 140 days (range 30 to 1080 days). Patients were interviewed at a median of 720 days (range 120 to 990 days) after removal of the final stent.

Results: Median age was 50 years (range 17 to 68 years); 78% were women. The etiology of stenosis of the orifice was sphincterotomy in 8, sphincteroplasty in 7 and papillectomy in 2 patients. Indications for treatment were abdominal pain (100%), dilated bile duct and/or main pancreatic duct (14 patients) and pancreas divisum (3 patients). Sixty procedures (median 4 per patient) were performed with mild morbidity (hospital stay less than 3 days) in 17% of procedures and 35% of patients. Symptoms improved in 100%, 57% and 33% of patients with bile duct, bile duct/main pancreatic duct and accessory pancreatic duct, respectively. Surgery was ultimately needed in 3 (43%) patients with bile duct/main pancreatic duct and 2 (67%) with accessory pancreatic duct stenosis.

Conclusions: Endoscopic therapy successfully relieves pain due to biliary stenosis of the orifice but less frequently relieves pain due to pancreatic stenosis of the orifice.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cholangiopancreatography, Endoscopic Retrograde*
  • Cholestasis / diagnosis
  • Cholestasis / therapy*
  • Constriction, Pathologic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Ducts / pathology*
  • Prospective Studies
  • Retrospective Studies