Serum levels of ifn-inducible PROTEIN-10 relating to the activity of systemic lupus erythematosus

Cytokine. 2000 Oct;12(10):1561-5. doi: 10.1006/cyto.2000.0757.


IFN-inducible protein-10 (IP-10) is supposed to act as a specific chemoattractant for Th(1)cells. Since Th(1)cells and IFN-gamma are shown to be important for developing systemic lupus erythematosus (SLE), we examined the relationship between serum IP-10 levels and the disease activity. Serum IP-10 levels were markedly increased in the SLE patients depending on the level of disease activity, whereas not in the patients with rheumatoid arthritis (RA). On the other hand, serum MCP-1 levels were increased to a similar extent both in RA and inactive SLE patients, and a little more elevated in active SLE patients. Serum IP-10 levels in SLE patients correlated positively and negatively with levels of anti-DNA antibody and complements, respectively, whereas MCP-1 levels correlated less or not at all. These results suggest that serum IP-10 levels could be a good indicator for the activity of SLE and that IP-10 could play an important immunological role in SLE.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arthritis, Rheumatoid / blood
  • Case-Control Studies
  • Chemokine CCL2 / blood
  • Chemokine CXCL10
  • Chemokines, CXC / blood*
  • Complement C3 / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / blood*
  • Lupus Erythematosus, Systemic / metabolism*
  • Male
  • Middle Aged


  • Chemokine CCL2
  • Chemokine CXCL10
  • Chemokines, CXC
  • Complement C3