Bacterial promoters triggering biodegradation of aromatic pollutants

Curr Opin Biotechnol. 2000 Oct;11(5):467-75. doi: 10.1016/s0958-1669(00)00126-9.

Abstract

Unraveling the complex transcriptional regulation of bacterial catabolism of aromatic pollutants is a prerequisite for engineering efficient biological systems for many biotechnological applications. A first level of regulation relies on specific regulator-promoter pairs. There have been new insights into the molecular mechanisms that regulatory proteins use to sense a given signal and to activate transcription initiation from the cognate promoters. A second level of regulation allows adjustment of the expression of the particular catabolic operons in response to the global environmental conditions of the cells, and recent findings provide some clues about the mechanisms underlying such complex regulatory checkpoints.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biodegradation, Environmental
  • DNA-Binding Proteins / metabolism
  • Environmental Pollutants / metabolism*
  • Gene Expression Regulation, Bacterial
  • Genes, Regulator*
  • Hydrocarbons, Aromatic / metabolism*
  • Operon
  • Polycyclic Aromatic Hydrocarbons / metabolism*
  • Promoter Regions, Genetic
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Environmental Pollutants
  • Hydrocarbons, Aromatic
  • Polycyclic Aromatic Hydrocarbons
  • Transcription Factors