Distribution and Properties of Glucagon Immunoreactivity in the Digestive Tract of Various Mammals: An Immunohistochemical and Immunochemical Study

Histochemistry. 1975 Sep 29;44(4):281-90. doi: 10.1007/BF00490364.

Abstract

Numerous epithelial cells in the oxyntic gland area of the stomach of cat and dog appear to store pancreatic-type glucagon, as evidenced by immunohistochemistry and--in the case of the dog--also by radioimmunoanalysis. No glucagon immunoreactive cells are found in the antropyloric mucosa. Disseminated cells in the intestinal mucosa store gut-type glucagon. In all species studied, these cells predominate in ileum and colon.

MeSH terms

  • Animals
  • Antigen-Antibody Reactions
  • Colon / immunology
  • Digestive System / immunology*
  • Dogs
  • Duodenum / immunology
  • Female
  • Fluorescent Antibody Technique
  • Gastric Mucosa / immunology
  • Gastrointestinal Hormones / immunology
  • Glucagon / immunology*
  • Histocytochemistry
  • Ileum / immunology
  • Intestinal Mucosa / immunology
  • Jejunum / immunology
  • Male
  • Organ Specificity
  • Pylorus / immunology
  • Radioimmunoassay
  • Rats
  • Species Specificity
  • Swine

Substances

  • Gastrointestinal Hormones
  • Glucagon