NMDA channel blockers: memantine and amino-aklylcyclohexanes--in vivo characterization

Amino Acids. 2000;19(1):167-72.


The previous overviews provided the basis for better therapeutic efficacy/tolerability of low to moderate affinity NMDA channel blockers. This prediction finds support in in vitro studies comparing protective and plasticity impairing effects (therapeutic vs. side-effect) of memantine and (+)MK-801. In fact it turned out that memantine had a far better therapeutic index. But can it be confirmed in the in vivo situation?

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclohexanes / pharmacology*
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Memantine / pharmacology*
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*


  • Cyclohexanes
  • Excitatory Amino Acid Antagonists
  • Receptors, N-Methyl-D-Aspartate
  • Memantine