Colorectal cancer update. Prevention, screening, treatment, and surveillance for high-risk groups

Med Clin North Am. 2000 Sep;84(5):1163-82, viii. doi: 10.1016/s0025-7125(05)70281-9.


Great advances have been made in understanding the cause and molecular genesis of colorectal cancer. The disease can be prevented by a healthful diet and lifestyle or by resecting the precursor of most of these cancers, the advanced adenomatous polyp. Screening the average-risk population plus special surveillance for high-risk groups now is recommended by evidence-based guidelines. Surgery is highly curative for patients without distant metastases, and adjuvant therapy improves survival in selected patients with advanced cancers.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyps / surgery
  • Colonic Neoplasms / etiology
  • Colonic Neoplasms / genetics
  • Colonic Neoplasms / prevention & control*
  • Colonic Neoplasms / surgery
  • Colonic Neoplasms / therapy
  • Colonic Polyps / surgery
  • Diet
  • Evidence-Based Medicine
  • Humans
  • Life Style
  • Mass Screening*
  • Molecular Biology
  • Neoadjuvant Therapy
  • Population Surveillance
  • Practice Guidelines as Topic
  • Precancerous Conditions / surgery
  • Rectal Neoplasms / etiology
  • Rectal Neoplasms / genetics
  • Rectal Neoplasms / prevention & control*
  • Rectal Neoplasms / surgery
  • Rectal Neoplasms / therapy
  • Risk Factors