Central effects of neuromedin U in the regulation of energy homeostasis

Biochem Biophys Res Commun. 2000 Oct 14;277(1):191-4. doi: 10.1006/bbrc.2000.3669.


Neuromedin U (NMU) is a brain-gut peptide whose peripheral activities are well-understood but whose central actions have yet to be clarified. The recent identification of two NMU receptors in rat brain has provided a springboard for further investigation into its role in the central nervous system. Intracerebroventricular administration of NMU to free-feeding rats decreased food intake and body weight. Conversely, NMU increased gross locomotor activity, body temperature, and heat production. NMU, a potent endogenous anorectic peptide, serves as a catabolic signaling molecule in the brain. Further investigation of the biochemical and physiological functions of NMU will help our better understanding of the mechanisms of energy homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Temperature / drug effects
  • Body Weight / drug effects
  • Eating / drug effects
  • Energy Metabolism / drug effects*
  • Homeostasis / drug effects*
  • Injections, Intraventricular
  • Locomotion / drug effects
  • Male
  • Neuropeptides / administration & dosage
  • Neuropeptides / pharmacology*
  • Oxygen Consumption / drug effects
  • Rats
  • Rats, Wistar
  • Thermogenesis / drug effects


  • Neuropeptides
  • neuromedin U