P300 as a clinical assay: rationale, evaluation, and findings

Int J Psychophysiol. 2000 Oct;38(1):3-19. doi: 10.1016/s0167-8760(00)00127-6.


Use of the P300 event-related brain potential (ERP) as a clinical assay is reviewed and assessed by comparing its distribution qualities with normative biomedical testing data from published studies. The coefficient of variation statistic was calculated for P300 data and a variety of clinical testing data. P300 amplitude and latency variability was found to be highly comparable and sometimes superior to routinely employed biomedical assays. These results are discussed in terms of how to control inter-group ERP variability and the application of normative P300 data in clinical settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acoustic Stimulation
  • Alzheimer Disease / diagnosis
  • Animals
  • Biomarkers
  • Circadian Rhythm / drug effects
  • Circadian Rhythm / physiology*
  • Event-Related Potentials, P300 / drug effects
  • Event-Related Potentials, P300 / physiology*
  • Humans
  • Nervous System Diseases / diagnosis*
  • Photic Stimulation
  • Psychophysiology


  • Biomarkers