The influence of diazepam on the electroencephalogram-evoked potential interrelation in rats

Neurosci Lett. 2000 Oct 27;293(2):83-6. doi: 10.1016/s0304-3940(00)01496-8.

Abstract

Though being a sedative, diazepam increases beta-activity in the electroencephalogram (EEG). Diazepam also affects auditory evoked potentials (AEPs). We investigated if the effect of diazepam on AEPs could be ascribed to its beta-increasing effect. Eight rats received vehicle and diazepam counterbalanced. AEPs were ranked in ten categories according to the percentages of beta-activity in the pre-stimulus electroencephalogram (EEG). With vehicle, the P(29), N(51) and P(67) AEP components increased and cross-correlation coefficients (CCCs) declined with increasing beta-activity. With diazepam AEP components and CCCs remained unchanged. All AEPs with diazepam closely resembled the AEP of the lowest beta-category obtained with vehicle. We conclude that the effect of diazepam on AEPs can not be ascribed to its beta-enhancing effect. Diazepam disrupts the normal AEP-EEG relation such that diazepam-effects on AEPs seem to reflect the sedative effects of diazepam and not its beta-increasing effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Beta Rhythm / drug effects
  • Diazepam / pharmacology*
  • Electroencephalography / drug effects*
  • Evoked Potentials, Auditory / drug effects*
  • Fourier Analysis
  • Hypnotics and Sedatives / pharmacology*
  • Male
  • Pharmaceutical Vehicles
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects

Substances

  • Hypnotics and Sedatives
  • Pharmaceutical Vehicles
  • Diazepam