Cerebral mucormycosis: proton MR spectroscopy and MR imaging

Magn Reson Imaging. 2000 Sep;18(7):915-20. doi: 10.1016/s0730-725x(00)00180-6.


Proton magnetic resonance spectroscopy (MRS) was integrated with magnetic resonance imaging (MRI) in the evaluation of a case of cerebral mucormycosis. MRS showed markedly elevated lactate, depleted N-acetyl aspartate and metabolite resonances attributable to succinate and acetate. The spectroscopy profile is essentially similar to that of bacterial abscess but without the commonly seen resonances of the amino acids valine, leucine and isoleucine. Our extensive literature review did not yield any reports of MRS findings on cerebral mucormycosis. MRS prospectively limited the differential diagnoses given the otherwise nonspecific and complex MR imaging findings in our immunosuppressed patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy, Needle
  • Brain / pathology*
  • Central Nervous System Fungal Infections / diagnosis*
  • Central Nervous System Fungal Infections / therapy
  • Fatal Outcome
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Mucormycosis / diagnosis*
  • Mucormycosis / therapy
  • Protons*
  • Sensitivity and Specificity


  • Protons