Preload dependence of color M-mode Doppler flow propagation velocity in controls and in patients with left ventricular dysfunction

J Am Soc Echocardiogr. 2000 Oct;13(10):902-9. doi: 10.1067/mje.2000.106572.


The purpose of this study was to assess the effects of preload alterations on color M-mode flow propagation velocity (Vp) in volunteers with normal left ventricular (LV) function and in patients with depressed LV function. Color M-mode Doppler echocardiography was performed during Valsalva maneuver, passive leg lifting, and after administration of nitroglycerin in 30 healthy volunteers and in 30 age- and sex-matched patients with previous myocardial infarction (MI). Mean Vp in controls was 74 +/- 15 cm/s at baseline and 46 +/- 15 cm/s in MI patients (P <.0005). In both groups, minor changes in Vp were seen during preload alterations; however, these were not significant (control P =.72, MI P =.31). In both groups, peak E-wave velocity (P <.0005), ratio of early-to-late peak velocities (P <.0005), and E-wave deceleration time (P <.0005) were found to change during preload alterations. In conclusion, we found that in controls and patients with previous MI, the color M-mode flow propagation velocity is not affected significantly by preload.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Flow Velocity
  • Echocardiography, Doppler, Color*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Ventricular Dysfunction, Left / diagnostic imaging*
  • Ventricular Function, Left*