Ticlopidine, Alka-Seltzer, or a combination of citric acid with aspirin: effects on platelet aggregation in individuals with an insufficient response to aspirin alone

Clin Appl Thromb Hemost. 2000 Oct;6(4):222-5. doi: 10.1177/107602960000600407.

Abstract

Aspirin (ASA) does not effectively lower platelet aggregation in all people. The platelet aggregation (PA) score is an easily used clinical method for measuring the effect in individuals of antiplatelet medications. Fifteen apparently healthy subjects (2 men and 13 women), selected for their resistance to ASA's antiaggregation effect, completed a sequential trial of ticlopidine, Alka-Seltzer, and ASA + citric acid (CTA). Ticlopidine was the strongest aggregation inhibitor and the ASA + CTA combination was more inhibitory than Alka-Seltzer. It was determined that measuring antiaggregation effects of a particular agent in an individual prior to usage would optimize treatment. The PA score methodology provides a means for testing patients prior to antiplatelet therapy for prevention and treatment of the thrombotic complications of vascular disease.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aspirin / administration & dosage
  • Aspirin / pharmacology
  • Citrates / administration & dosage
  • Citrates / pharmacology
  • Citric Acid / administration & dosage
  • Citric Acid / pharmacology
  • Drug Combinations
  • Drug Therapy, Combination
  • Female
  • Humans
  • Male
  • Middle Aged
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / administration & dosage*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Sodium Bicarbonate / administration & dosage
  • Sodium Bicarbonate / pharmacology
  • Ticlopidine / administration & dosage
  • Ticlopidine / pharmacology

Substances

  • Citrates
  • Drug Combinations
  • Platelet Aggregation Inhibitors
  • Citric Acid
  • sodium acetylsalicylate, sodium bicarbonate, sodium citrate drug combination
  • Sodium Bicarbonate
  • Ticlopidine
  • Aspirin