Central venous catheter-related infections in children on long-term home parenteral nutrition: incidence and risk factors

Clin Nutr. 2000 Oct;19(5):355-9. doi: 10.1054/clnu.2000.0132.


Background and aims: This study aimed to assess the incidence and etiology of central venous catheter (CVC) infections in children on home parenteral nutrition (HPN).

Methods: 207 CVC-years were studied retrospectively in 47 children on HPN, aged 8.1+/-5.0 years.

Results: 125 CVC were used (means: 2.6 CVC/patient and 21 months utilization/CVC). Half of the hospitalizations (162) were due to proven CVC-related infections. The mean infection incidence was 2. 1/1000 HPN days. The total population divided in two groups below and above this value: group one including 24 children, incidence < or = 2.1 per 1000 days (mean: 0.83) and group two including 23 children, incidence >2.1 per 1000 days (mean: 4.3). No differences were found between the two groups in terms of underlying disease, presence of ostomies, age at the time of HPN onset, or micro-organisms responsible. The only differences (p<0.05) were the mean duration of HPN (longer in group one) and the delay between HPN onset and the first infection (longer in group one).

Conclusions: This study does not highlight any risk factors for CVC infection. However, early CVC infections after HPN onset appear to predict a bad prognosis.

MeSH terms

  • Adolescent
  • Catheterization, Central Venous / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Infections / epidemiology*
  • Infections / etiology
  • Infections / therapy
  • Male
  • Parenteral Nutrition, Home*
  • Retrospective Studies
  • Risk Factors