Biomedicine. Staying slim with insulin in mind

Science. 2000 Sep 22;289(5487):2066-7. doi: 10.1126/science.289.5487.2066.

Abstract

Striking the delicate balance between energy intake in the form of food and energy expenditure in the form of metabolic activity keeps the body extremely busy. As Schwartz explains in his enlightening Perspective, the finding that insulin signals the brain to promote weight loss (Brüning et al.) flies in the face of the notion that insulin is involved solely in glucose storage, its conversion to fat, and weight gain.

Publication types

  • Comment

MeSH terms

  • Adipocytes / physiology
  • Animals
  • Blood Glucose / analysis
  • Body Weight*
  • Brain / physiology*
  • Eating
  • Female
  • Insulin / physiology*
  • Leptin / physiology
  • Male
  • Mice
  • Neurons / physiology
  • Obesity / etiology
  • Receptor, Insulin / physiology*
  • Signal Transduction
  • Weight Loss

Substances

  • Blood Glucose
  • Insulin
  • Leptin
  • Receptor, Insulin