Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Nov;67(5):1251-76.
Epub 2000 Oct 16.

Tracing European Founder Lineages in the Near Eastern mtDNA Pool

Affiliations
Free PMC article

Tracing European Founder Lineages in the Near Eastern mtDNA Pool

M Richards et al. Am J Hum Genet. .
Free PMC article

Abstract

Founder analysis is a method for analysis of nonrecombining DNA sequence data, with the aim of identification and dating of migrations into new territory. The method picks out founder sequence types in potential source populations and dates lineage clusters deriving from them in the settlement zone of interest. Here, using mtDNA, we apply the approach to the colonization of Europe, to estimate the proportion of modern lineages whose ancestors arrived during each major phase of settlement. To estimate the Palaeolithic and Neolithic contributions to European mtDNA diversity more accurately than was previously achievable, we have now extended the Near Eastern, European, and northern-Caucasus databases to 1,234, 2, 804, and 208 samples, respectively. Both back-migration into the source population and recurrent mutation in the source and derived populations represent major obstacles to this approach. We have developed phylogenetic criteria to take account of both these factors, and we suggest a way to account for multiple dispersals of common sequence types. We conclude that (i) there has been substantial back-migration into the Near East, (ii) the majority of extant mtDNA lineages entered Europe in several waves during the Upper Palaeolithic, (iii) there was a founder effect or bottleneck associated with the Last Glacial Maximum, 20,000 years ago, from which derives the largest fraction of surviving lineages, and (iv) the immigrant Neolithic component is likely to comprise less than one-quarter of the mtDNA pool of modern Europeans.

Figures

Figure  1
Figure 1
Age ranges for major founder clusters—namely, those comprising ⩾40 lineages (which comprise 76% of the European data set), under the fs criterion. The proportion of lineages in each cluster is indicated. The 95% (50%) CRs for the age estimates of each cluster are shown by white (black) bars. The age classes used in the partition analysis are also indicated. Since the U* founder cluster (incorporating U5 under fs) is very non-starlike, its CRs are certainly underestimated. Although frequent, the cluster U5a1 is not shown, since it is probably of European origin, as discussed in the text.

Similar articles

See all similar articles

Cited by 238 articles

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources

Feedback