Bedside measurement of D-dimer in the identification of bacteremia in the emergency department

J Emerg Med. 2000 Oct;19(3):217-23. doi: 10.1016/s0736-4679(00)00230-4.


The objective of this pilot study was to determine the clinical utility of the SimpliRed D-dimer bedside assay to identify patients with bacteremia in a university hospital Emergency Department. We tested 265 patients and compared blood culture results with a novel D-dimer semiquantitative whole blood assay. Bacteremia was confirmed in 25/262 patients. Sensitivity of D-dimer assay was 66.7% for Gram-positive bacteremia and 61.5% for Gram-negative bacteremia with negative predictive value of 98% for Gram-positive and 96% for Gram-negative bacteremia patients. Measurement of D-dimer appears to be of value in identifying patients at low risk for bacteremia and can be accomplished rapidly using a whole blood semiquantitative bedside assay. Although increases in D-dimer are not detected in all patients subsequently documented to have bacteremia on a single sampling, the results of this and other earlier studies suggest assay of D-dimer is useful in rapid differentiation of patients with bacteremia from those who have no bacteremia using blood culture positivity as the standard for bacteremia.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Agglutination Tests / methods
  • Bacteremia / diagnosis*
  • Emergency Service, Hospital*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Hospitals, University
  • Humans
  • Male
  • Oklahoma
  • Pilot Projects
  • Point-of-Care Systems*
  • Predictive Value of Tests


  • Fibrin Fibrinogen Degradation Products