Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges

J Cataract Refract Surg. 2000 Oct;26(10):1543-9. doi: 10.1016/s0886-3350(00)00426-0.


Purpose: To compare the preventive effect on posterior capsule opacification (PCO) of an acrylic intraocular lens (IOL) and a silicone IOL, both with sharp rectangular optic edges.

Setting: Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.

Methods: After phacoemulsification, an acrylic IOL (AcrySof(R)) was implanted in 1 eye and a silicone IOL (CeeOn 911) in the contralateral eye of 7 rabbits, one of which was omitted from evaluation.

Results: The Miyake-Apple view and histopathological findings 3 weeks after surgery revealed that the lens capsule wrapped tightly around the optic edges, conforming to a distinctly sharp bend, with both IOL types in 5 rabbits. Migrating lens epithelial cells (LECs) were inhibited at the site. The AcrySof IOL had a better capsular bend effect in the histological sections, but there was no apparent difference in PCO development between the 2 IOLs.

Conclusions: The CeeOn 911 silicone IOL, with sharp rectangular optic edges, showed an effect on preventing PCO that was similar to that of the AcrySof IOL. When a discontinuous capsular bend is created by an IOL with sharp optic edges, the bend may induce contact inhibition of migrating LECs regardless of the lens' material composition.

Publication types

  • Comparative Study

MeSH terms

  • Acrylic Resins
  • Animals
  • Cataract / etiology
  • Cataract / pathology
  • Cataract / prevention & control*
  • Cell Adhesion
  • Cell Movement*
  • Epithelial Cells / pathology*
  • Lens Capsule, Crystalline / pathology*
  • Lens Implantation, Intraocular / instrumentation*
  • Lenses, Intraocular*
  • Phacoemulsification / adverse effects
  • Prosthesis Design
  • Rabbits
  • Silicone Elastomers
  • Surface Properties


  • Acrylic Resins
  • Silicone Elastomers