[Dantrolene-induced pleurisy: a case report]

Rev Pneumol Clin. 2000 Sep;56(4):261-3.
[Article in French]


We report the case of a patient who developed dantrolene-induced pleurisy. Dantrolene (Dantrium) is a muscle relaxing agent used for the treatment of spastic neurological manifestations which has known liver toxicity. Lung toxicity is rarely reported. Six cases of dantrolene-induced pleurisy occurring after chronic administration (> 60 days) have been described in the literature. The pleurisy is associated with pleural and peripheral eosinophilia. Spontaneous regression a few days after withdrawal and radiological cure a few months later is the rule. The precise mechanism of this drug-induced pleural reaction remains unknown.

Publication types

  • Case Reports
  • Comparative Study
  • English Abstract

MeSH terms

  • Aged
  • Dantrolene / adverse effects*
  • Follow-Up Studies
  • Humans
  • Male
  • Muscle Relaxants, Central / adverse effects*
  • Muscle Spasticity / drug therapy
  • Pleurisy / chemically induced*
  • Pleurisy / diagnosis
  • Time Factors


  • Muscle Relaxants, Central
  • Dantrolene