Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections

Neuroimage. 2000 Nov;12(5):582-7. doi: 10.1006/nimg.2000.0654.


Cross-correlation of low-frequency temporal fluctuations (<0.08 Hz) was used to correlate widely separated anatomic regions during continuous performance of a spatial working memory task. The regions of highest correlation to right-hemisphere dorsolateral prefrontal cortex correspond to the regions of largest baseline signal change in a conventional block-style functional MRI paradigm. Additionally, it is shown that the correlations between elements of the functional network increase during performance of a task that activates the network when compared to a task that does not directly stimulate the functionally connected network.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Attention / physiology
  • Brain Mapping
  • Cerebral Cortex / physiology*
  • Dominance, Cerebral / physiology*
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging*
  • Mental Recall / physiology*
  • Nerve Net / physiology*
  • Orientation / physiology*
  • Prefrontal Cortex / physiology
  • Psychomotor Performance / physiology