The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection

E Kunstmann; C Hardt; E Elitok; M Harder; S Suerbaum; U Peitz; W Schmiegel; J T Epplen

doi:10.1128/IAI.68.11.6493-6495.2000

The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection

Infect Immun. 2000 Nov;68(11):6493-5. doi: 10.1128/IAI.68.11.6493-6495.2000.

Authors

E Kunstmann¹, C Hardt, E Elitok, M Harder, S Suerbaum, U Peitz, W Schmiegel, J T Epplen

Affiliation

¹ Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany. Erdmute.M.Kunstmann@rurh-uni-bochum.de

Abstract

To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0. 00063).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Genetic Predisposition to Disease
Helicobacter Infections / etiology*
Helicobacter pylori / genetics*
Helicobacter pylori / pathogenicity
Humans
Microsatellite Repeats
Polymorphism, Genetic
Receptors, Antigen, T-Cell, alpha-beta / genetics*

Substances

Receptors, Antigen, T-Cell, alpha-beta